BioSequence
Entity
EntityValue
Molecule
ResourceFunction

Life Sciences

Biological Sequences of Insulin across Species

Visualize and analyze biomolecular sequences including DNA and peptide sequences

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Use BioSequence to describe Human insulin, composed of two peptide sequences with three sets of bonds:

In[1]:=

insulin=BioSequence[{BioSequence["Peptide","FVNQHLCGSHLVEALYLVCGERGFFYTPKT"],BioSequence["Peptide","GIVEQCCTSICSLYQLENYCN"]},{Bond[{{2,1,6},{2,1,11}}],Bond[{{2,1,7},{1,1,7}}],Bond[{{2,1,20},{1,1,19}}]}]

Out[1]=

BioSequence

Collection of Sequences (Peptide, Peptide)

2 sequences

FVNQHLC…, GIVEQCC…

(51 total letters)



Convert to a Molecule to explore the structural details:

In[2]:=

mol=Molecule[insulin]

Out[2]=

Molecule

Formula:

257

383

Atoms:

788

Bonds:

799



Use MoleculePlot to visualize the insulin molecule:

In[3]:=

MoleculePlot[mol]

Out[3]=

Compare the sequence of insulin across multiple species. Start by obtaining the insulin coding gene for each organism:

In[4]:=

ins=Interpreter["Gene",AmbiguityFunctionAll]["insulin gene"]

Out[4]=

AmbiguityList

insulin

(human)

insulin

(cow)

preproinsulin

(zebrafish)

insulin

(dog)

insulin

(chimpanzee)

insulin

(chicken)

,insulin gene,{DescriptionINS (human gene),DescriptionINS (cow gene),Descriptionins (zebrafish gene),DescriptionINS (dog gene),DescriptionINS (chimpanzee gene),DescriptionINS (chicken gene)}

Use the DNAAlingmentPlot function from the Wolfram Function Repository to create a one-to-one alignment plot of human and cow insulin:

In[5]:=

ResourceFunction["DNAAlignmentPlot"]BioSequence

insulin

(human)

GENE

2,BioSequence

insulin

(cow)

GENE

2,Method"OneOnOne"

Out[5]=

Use the PhylogeneticTreePlot function to create a dendrogram derived from these genes:

In[6]:=

ResourceFunction["PhylogeneticTreePlot"][BioSequence[#]〚2〛&/@ins〚1〛,EntityValue[ins〚1〛,"Species"]]

Out[6]=

Of the compared species, human insulin is closest to chimpanzee insulin.

Related Symbols

BioSequence
Entity
EntityValue
Molecule
ResourceFunction

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Contributed by: Wolfram Staff

Wolfram Language Example Repository

Biological Sequences of Insulin across Species

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