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Related Pages
Related Symbols
SystemModel
SystemModelSimulate
SystemModelPlot
Related Categories
System Modeling
Life Sciences
Estimating Liver Function
A model-based approach to contrast agent transport
Example Notebook
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Download the BioChem library from the
System Modeler Modelica Library Store
.
Import the library:
I
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=
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Load the model:
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m
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;
View the model diagram:
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Run a simulation for a healthy individual:
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{
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,
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8
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]
;
Show contrast agent dynamics:
I
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p
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Patients with impaired liver function have a decreased transport of contrast agent to the liver.
Define parameter distributions for contrast agent transport to the liver.
"Healthy" parameters:
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;
"Diseased" parameters (from patients with the highest fibrosis grade):
I
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Plot the distributions:
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Simulate 100 samples from each population and compare contrast agent concentrations in the liver:
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;
Retrieve mean and standard deviation values at each time point:
I
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;
Patients with reduced liver function have a lower concentration of contrast agent in the liver. Set up plots for healthy and impaired patients:
Show the two plots in a single visualization:
External Links
A Mathematical Modeling Approach to Monitoring Liver Function in Drug Trials
Related Symbols
SystemModel
SystemModelSimulate
SystemModelPlot
Publisher Information
Contributed by:
Jan Brugård
